Effects of syphilis on pregnancy: The treponema pallidum affects the placenta and the foetus in pregnancy. The effects are usually observed after 20th week of the pregnancy. In recent virulent infection, there is a possibility of abortion. Otherwise there are risks of intrauterine foetal death, stillborn and macerated foetus; baby may be borned alive with evidences of syphilis or the baby is borned with other health issues or healthy but develops syphilitic lesions later in the infancy or childhood. Placenta in the seriously infected cases may be relatively bulky in size with microscopical evidences of increased size of the villi due to increased cellularity, perivascular round cell infiltration and diminution in the vascularity of the villi. Spirochetes can be hardly found in placenta.
Effects of pregnancy on Syphilis: Pregnancy causes suppression or latency of syphilitic manifestations. Likewise serum reactions in pregnancy may be modified.
Treatment: Early diagnosis should be made and early institution of treatment should be started. Penicillin treatment at present is considered the therapy of choice for syphilitic pregnant women.
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